15 Powerful Prayers for Supernatural Breakthroughs

When Satan is running free, it is important to keep God on your side. Here are 15 powerful prayers for supernatural breakthroughs.

Prayer for Spiritual Guidance in Unexpected Suffering
Precious Holy Spirit, I plead with You, precious Holy Spirit! I need You now! I am feeling shocking and unexpected pain. I am in crisis. I am suffering greatly. I cannot see a way out. I do not know what to do. I feel stuck in darkness and hopeless. You know all this. I do not have to explain. I cannot see You but I know You are working in me. Calm my mind so I can hear You speak to me, precious Holy Spirit. Guide my thoughts so I can understand what to do next, what steps to take to alleviate my pain and put me on a new path. Show me Your will for my life. I trust Your will. I trust Your plan. Holy Spirit, show me the way. Get me out of the darkness, I cry to You! In Your name, Amen.

Prayer for My Unbelief
Merciful and Forgiving Lord, I have a secret that I am too ashamed to talk about. Everyone thinks I am a Christian, but am I? My head believes in You, and I want my heart to follow, but it is just so hard for my overthinking brain to get there. There is evidence for You. There is more evidence for You than against You. So why my unbelief? Come into my heart and fill me with You. I need more of You to help my unbelief. With more of You in me, I will be able to wipe away my doubt in Your existence. Chase me down, Lord, and bring me close to You. I believe. Help my unbelief. Amen.

Prayer for My Addiction
Way Maker, Miracle Worker, I need You now. I am weak. I do not want to give in to my urges, but it is so hard to go through the day without the escape, the release, and the euphoria. I need Your divine intervention to strengthen my resolve to stop. I need You to help me find substitutes that comfort me. Make me busy with something else to divert and occupy my mind. Turn my life around. Help me make small steps each day – cutting back – delaying…come into me, Lord. Fill me with Your strength. Give me the power, through You, to beat my demons. I need You, Lord. I need You. You are my Light in the Darkness. I cannot do this on my own. Amen.

Prayer for My Lost Soul
God of Victory, I am a lost soul. I have done so much wrong and caused so much pain. I have turned away from what You taught me and lived as I pleased. I did what I wanted, so long as it made me happy. I put my pleasure first in all things. You say I am worthy, but I feel dirty. Make me clean. Chase me down and fight for me, oh God. Find me and lay me on your shoulders, as your lost sheep. Amen.

Prayer for My Physical Healing
Jesus, the Great Physician, I ask for Your healing power. I am very ill and hopeless. I need You now. I don’t want this damaged shell of a body anymore. I want a new body. I want to start over. I want to be healthy and vibrant. Work a miracle on my body as You have done for so many others. Breathe Your healing power into my limp frame and give me a brand new body, dear Jesus. Make it clean and strong. Run Your holy power through my veins. Rescue Your child who cries out to You, Jesus. Give me hope that You will have mercy on me and make me new. In Your holy name, I pray, Amen.

Prayer for Perseverance
Sovereign and Righteous Lord, I have been struggling for some time with my life and need for Your help. I have relationship issues, financial issues, and health issues. There is so much going on and I am seeking a spiritual breakthrough so that I can take the steps to put things into place. You say that Your Holy Spirit is with us wherever we go. Be with me today. Be inside me. Direct me. I am listening. Give me the strength to go on through all these struggles. I need Your divine intervention to persevere. I need Your energy to flow through my veins. Lord, I need You now. In Jesus’ name, Amen.

Prayer for Facing Difficult Choices
Maker of Heaven and Earth, I do not know what to do. I have an unbelievably tough decision to make, and no matter which I choose, I feel like it might not be right. You say that we do not have because we do not ask. I am asking today, Jesus. You are my Light in the Darkness. Illuminate the path and show me the right choice. Make my decision painfully obvious, Jesus. I trust You more than anyone, Jesus. Please let Your will be known. In Jesus’ Name, Amen.

Prayer for Discipleship
O God of Enduring Faithfulness, I believe in You and want to follow You in my actions every day. I want to learn from You, by studying Your word and listening to others teach it. I ask today that You open my eyes. Open my eyes to the Holy Spirit. Soften my heart as You did Pharaoh. Flow Your holy words through my mouth. Keep the devil out of my path to You, Lord. Allow me to spread the good word for You as Jesus’ disciples did for Him. Make me into Your holy servant. In Jesus’ name, Amen.

Prayer to Conquer My Temptation for Pornography
God of Heaven’s Armies, You say that You will not tempt us with more than we can stand. You say that when we are tempted, that You will show us a way out of that temptation. Lord God, plant in my hand the sword of the Holy Spirit to fight my lustful desires of the flesh. Sex surrounds me, on TV, in music, in magazines, and on the internet. Fight my demons and help me hold fast to Your commandment against sexual activities outside of marriage. The temptation is too strong – I cannot fight the devil without You. Run Your power through me and fill me with Your divine resolve to deny sin its chance to strangle my life! In the name of Jesus Christ, Amen.

Prayer for a Renewed Mind
Father, my Miracle-Worker, I have been so focused on things of this mortal world that I have neglected the life inside of me. Transform my mind and spirit and dig up the treasure You have planted deep within me. Change my thoughts so that I treat my body like a temple of the Holy Spirit, who is in me. Guard my lips and make only Your words come from my mouth. Lead me by Your Spirit. In Jesus’ name, Amen.

Prayer for Doctors
Righteous Savior, bestow wisdom on the doctors who treat the ill. Let them be steadfast in their ability. Give them the recall needed to help heal those that they treat. Give them the confidence to perform their surgeries and their treatments necessary to mend. Lord, if sorrow should fall on those very doctors, be with them in their time of need. Dry their tears and take away their sadness. In the name of Your Son, Jesus Christ, Amen.

Prayer for Deliverance from Evil
Lord, Chain-Breaker, as I go through my day, strike down evil that crosses my path. Arm me with the helmet of salvation and the sword of the Spirit all day long. Open my eyes so I can see temptation coming before it gets too close. Clear a path for me to escape from it. Give me the desire and the strength to run from it right away. Give me refuge in Your word. You say that I will not be tempted beyond my ability, and in this, I believe. I place my trust in You, Lord God. Amen.

Prayer for Sadness (or Depression)
God of All Comfort, I am deeply sad. My world is dark and I have no desire to move or breathe. I cannot read Your word right now. Why have You forgotten me? Where is Your mercy? Where is my hope? You say You care for me. You say You will never forsake me. My God, I cry out to You, lost in my dark abyss, asking You to put Your arms around me and pull me out. Flood me with light. Motivate me to get out of bed and go for a walk. Give me the will to move forward. Use my tears to bring hope to others who are hurting. Lord God, I need You now more than ever. In Jesus’ name, Amen.

Prayer Against My Goliath
God, my Fortress, I am immobilized with my own Goliath in my own Valley of Elah. Please, God, fill me with David’s deep confidence in You that gave this shepherd boy the courage to fight the massive Goliath of Gath. David knew he had been chosen by God to be the next king of Israel. I know I am Your child and am to take every thought captive to obey You. I take up a shield of faith and the sword of Your word against my Goliath. My Goliath is not bigger than You, God. My faith in You gives me courage. I will defeat the enemy. In Jesus’ name, Amen.

Prayer in the Hour of My Death
Most Merciful God, at the hour of my death, know that I have loved You. I have not always done the right thing. I have not always said the right thing. I have not prayed enough. I have not tithed enough. You say that if we confess our sins, that you will forgive us and cleanse us from all unrighteousness. You will not punish us as we deserve, but will have mercy on us. I confess, almighty Father. I confess my sins and shortcomings. I confess the pain I have caused. I confess not honoring You in my life above all people and all things. Please make me clean and bring me home to You. In the moments after my death, open the sky to heaven and lead me there to be with You. In Jesus’ name, Amen.

Most Popular Prayers by Topic

For Hard Times
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For Physical Health
For Emotional Health
For Protection
For a Marriage
For Babies and Pregnancy
For Family
For Spiritual Warfare
For Spiritual Health
For a Death
For the Workplace
For Bedtime

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Author Bio
Natalie Regoli is a child of God, devoted wife, and mother of two boys. She has a Master's Degree in Law from The University of Texas. Natalie has been published in several national journals and has been practicing law for 18 years.