20 Most Powerful Prayers for Overcoming Depression

Deuteronomy 31:8
Dear Lord, I pray against the negative thoughts that occupy my mind right now. I pray for a peace of mind that surrounds me and keeps me. Your word says that You go before me and will be with me; You will never leave me nor forsake me. Father, please give me the strength to not be afraid; nor be discouraged. I pray that You strengthen me in all areas especially emotionally, mentally and spiritually so that I can overcome the obstacles that have me, Amen.

Psalm 34:17
Heavenly Father, my heart cries out to You right now in my time of great adversity. Depression has kept me trapped in a state of despair. But I pray Lord that You hear my cries and deliver me from my troubles. I pray that You make me whole again and fill me with the peace that You have promised me. I know that through You, I will be delivered and through You I will be made whole. Lord, I thank You in advance for my deliverance, Amen.

Psalm 40:1-3
Righteous God, I wait patiently for You, because I know that You turn to me and hear my cries. I know that You will lift me out of this dark period, You will set my feet on a rock and give me a firm place to stand. Because of You, I will have a new song to sing, a hymn of praise to You. Father, I praise You because You are my joy and my hope. I praise You because I know that You are the reason that I will overcome my depression, Amen.

Psalm 3:3
Holy God, I have allowed myself to believe the lies that the enemy wants me to believe. I have allowed myself to believe that I am alone and that I am weak. But Lord, Your word tells me that You are a shield around me, my glory, the One who lifts my head high. I do not have to carry negativity on my shoulders, when You are the one who lifts me up in Your perfect peace. How can I be weak when You (my Mighty Warrior) are my great defense? Amen.

Psalm 32:10
Eternal God, I place my trust in You and I know that Your unfailing love surrounds me. I pray that at my lowest point, I remember that I am surrounded by Your love. I pray that when I feel the pressures of life, I remember that You surround me with Your love. I declare peace in life’s pressure, joy in my despair and strength in my weakness. In Jesus’ Name, I will overcome my depression, Amen.

Psalm 42:11
God of Peace, I thank You for Your word and pray that it continues to guide me daily. Depression is a struggle, but I take back authority in my life. Why, my soul, are you downcast? Why so disturbed within me? Why do I let negative thinking rule my mindset? Lord renew my mind and guide my thoughts. I put my hope in You and I will praise You because You are my Savior and my God. I will no longer accept my state of depression because it is not what You intended for me, Amen.

1 Peter 5:6-7
Precious Lord, I cast all my anxiety on You because You care for me. You do not want me to be bound by depression or anxiety, You want me to live freely in You. I thank You because I know that under Your mighty hand, I will be lifted up in due time. I pray that in this season of depression I continue to worship You through it because You are my God who will never leave me nor forsake me, Amen.

John 16:33
Eternal Savior, each day brings a new challenge for me and I feel the burden weighing me down. But I declare Your word over my life right now because in You I may have peace. In the world I will have trouble, but I pray that I take heart and be of good cheer because You have overcome the world! Every circumstance that oppresses me has already been overcome by You, so I declare a spirit of power in my life right now, Amen.

Romans 8:38-39
God of Love, Your word tells me that neither death nor life, nor angels nor demons, neither the present nor the future, nor any powers, neither height nor depth, nor anything else in all creation, will be able to separate me from the love that is in You – Christ Jesus, my Lord. Even when I struggle to love myself or even love life, You love me. Your love surrounds me and I pray that this word uplifts me when I feel down, Amen.

2 Corinthians 1:3-4
Hallelujah to Your Name Father! Praise be to You, the Father of compassion and the God of all comfort, who comforts all in their times of trouble. I know that I can find comfort in You because You hear me and see me in my state of depression. Lord, I thank You for being my comfort because I know that I then will be able to comfort those in any trouble with the same comfort that I have received from You, Amen.

1 Peter 4:12-13
Holy God, I know that I should not be surprised at the intense ordeal that has come to test me, it is not strange to be a child of God and suffer as this is a part of life here on earth. But help me find the strength to rejoice in the sufferings that I have endured, so that I may be overjoyed when Your glory is revealed. Lord I declare that I shall have joy and will see Your glory revealed in my life, Amen.

Psalm 37:23-24
Dear Lord, Your word says that it is You who makes firm the steps of the one who delights in You; though I may stumble, I will not fall, for You uphold me with Your hand. Lord, I thank You for being the rock that I can lean on and the hand that will never let go, no matter how hard it gets. I know that I must trust in You because with You I can overcome the feelings of depression that I have experienced, Amen.

Philippians 4:13
Awesome God, I know that I can do all things through You who strengthens me, but I have tried to stand on my own. I have let go of You and relied on myself which is why I am now in a state of depression. I have let myself become isolated mentally, emotionally and spiritually. But Lord, I want to overcome this depression through You, I want to be free through You. Thank You in advance for my victory, Amen.

Isaiah 41:10
Righteous God, Your word tells me not to fear, for You are with me. I shouldn’t be dismayed for You are my God, You will strengthen me and help me. I pray that You uphold me with Your righteous right hand in my state of depression. I declare Your word over my life, and I pray against depression and the affect it has had on me. I declare that I will overcome this season of depression and I will walk in the peace that You have blessed me with, Amen.

John 10:10
Holy One, I know that the thief comes only to steal and kill and destroy, but today I choose to take back authority in my life (regardless of the thief’s intentions). I pray for Your divine protection over the things that the enemy seeks to take from me or destroy. Lord, You came so that I may have life and have it abundantly, so help me to walk in Your promise. Help me to let go of my depression and walk in liberty, Amen.

Matthew 11:28
Father, I have labored, and I am heavy laden. Depression has placed such a weight on my life that my mind feels burdened. Each day feels like a burden. But Lord, in You I find my rest, so I come to You today. I come to You knowing that You will take the burden of depression from me. I come to You knowing that I can let go of all my burdens and anxieties and walk in peace with You, Amen.

Jeremiah 29:11
Holy Savior, You know the plans that You have for me, and despite how I feel, I know that Your plans are not to harm me, nor are they for evil, but they are set out to give me hope and a future. Depression has allowed me to forget this, I have forgotten that my life is full of things that You give me for my own good. Life with You is a life with good things, Amen.

Psalm 30:11
Righteous God, Your word says that You can turn my mourning into dancing; You can loosen my mourning clothes and clothe me with gladness. I pray that You clothe me with joy so that I can be free from the depression that weighs me down. I pray for an increase in peace and hope in my life so that I can live unburdened. I pray against the plans of the enemy to oppress me, Amen.

Psalm 143:7-8
Hear my cries precious Lord as my spirit fails me. Please don’t hide Your face from me and let me not be forgotten. I pray that when I wake in the morning, I am reminded of Your steadfast love. I pray that I choose to put my trust in You rather than myself. My depression wants me to remain in the darkness and isolation, but I pray against this. I pray that You guide me to where I need to go so that my soul can be uplifted, Amen.

Psalm 30:5
God of Heaven, I know that Your anger is but for a moment, but Your favor is for a lifetime. Honestly, I feel as though I have lost Your favor on my life because my depression has encouraged me to believe my lies. But I declare Your word that weeping may last in the night, but joy comes in the morning. My despair is only for a season, but joy is promised for a lifetime. Hope is promised for a lifetime, Amen.

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Author Bio
Natalie Regoli is a child of God, devoted wife, and mother of two boys. She has a Master's Degree in Law from The University of Texas. Natalie has been published in several national journals and has been practicing law for 18 years.